Prenatal diagnosis of caudal regression syndrome without maternal diabetes mellitus

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Prenatal diagnosis of caudal regression syndrome without maternal diabetes mellitus.

Caudal regression syndrome is a rare congenital malformation with varying degrees of early gestational developmental failure. It is also known as sacral agenesis or caudal dysplasia. The cause of this malformation is thought to be defects in neuralization around the 28th day of the gestational period. Although maternal uncontrolled diabetes, genetic predisposition and vascular hypoperfusion are...

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Caudal regression syndrome: a case of early prenatal diagnosis without maternal diabetes Síndrome de regressão caudal: um caso de diagnóstico pré-natal precoce sem diabetes materna

C regression syndrome (CRS) is a complex, heterogeneous constellation of congenital caudal anomalies affecting the caudal spine and spinal cord, the hindgut, the urogenital system, and the lower limbs1. CRS is caused by developmental field defects of blastogenesis involving the caudal mesoderm2. Evidence has indicated that maternal diabetes may play a role in the pathogenesis of this condition2...

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Prenatal diagnosed caudal regression syndrome

Background: Caudal regression syndrome (CRS) is a rare complex congenital anomaly which is characterized by agenesis of the sacral and lumbar spine. Pelvis, lower extremity, genitourinary, cardiac anomalies and lower extremity neurological and motor development deficits may be accompanied. The exact etiology is unclear but the maternal insulin-dependent diabetes mellitus (hyperglycaemia during ...

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Prenatal diagnosis of Caudal Regression Syndrome : a case report

BACKGROUND: Caudal regression is a rare syndrome which has a spectrum of congenital malformations ranging from simple anal atresia to absence of sacral, lumbar and possibly lower thoracic vertebrae, to the most severe form which is known as sirenomelia. Maternal diabetes, genetic predisposition and vascular hypoperfusion have been suggested as possible causative factors. CASE PRESENTATION: We r...

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Familial caudal regression anomalad and maternal diabetes.

A family is reported which a diabetic woman gave birth to two children with the caudal regression anomalad (CRA). There were no obvious genetic factors. This is the first reported familial case of CRA with maternal diabetes.

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ژورنال

عنوان ژورنال: Journal of the Turkish German Gynecological Association

سال: 2011

ISSN: 1309-0399,1309-0380

DOI: 10.5152/jtgga.2011.43